Effect of magnetite nanoparticles on living rate of MCF-7 human breast cancer cells.

Abstract

Superparamagnetic and ferromagnetic magnetite nanoparticles, with diameters of approximately 13 and 44 nm, respectively, were synthesized and their uptake amount and heating efficiency were evaluated for application to magnetic hyperthermia. Both nanoparticles had almost the same zeta-potential (+10.2 mV) and hydrodynamic size (∼1 μm) and there was no significant difference in their uptake amount 18 h after they were added to the medium. After internalization, the ferromagnetic nanoparticles incorporated in human breast cancer cells (MCF-7) showed a higher heating efficiency than the superparamagnetic nanoparticles when an external magnetic field (4 kW, 250 kHz) high enough to produce heat by hysteresis loss was applied, followed by cellular death of MCF-7 with high ferromagnetic nanoparticle content.

• Authors: Daisuke Baba, Yasuhiro Seiko, Takuya Nakanishi, Hong Zhang, Atsushi Arakaki, Tadashi Matsunaga, Tetsuya Osaka
• Journal: Colloids and surfaces. B, Biointerfaces (Colloids Surf B Biointerfaces) Vol. 95 Pg. 254-7 (Jun 15 2012) ISSN: 1873-4367 [Electronic] Netherlands
• PMID: 22486944 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier B.V. All rights reserved.

Chemical References

• Antineoplastic Agents
• Ferrosoferric Oxide

Topics

• Antineoplastic Agents (chemical synthesis, chemistry, pharmacology)
• Breast Neoplasms (drug therapy, pathology)
• Cell Proliferation (drug effects)
• Drug Screening Assays, Antitumor
• Female
• Ferrosoferric Oxide (chemical synthesis, chemistry, pharmacology)
• Humans
• Nanoparticles (chemistry)
• Particle Size
• Structure-Activity Relationship
• Surface Properties
• Temperature
• Tumor Cells, Cultured