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Solitary, multifocal and generalized myofibromas: clinicopathological and immunohistochemical features of 114 cases.

AbstractAIMS:
  To report a large series of solitary and multiple myofibromas with systematic clinicopathological correlations.
METHODS AND RESULTS:
  We report on 114 patients with myofibromas, 97 of which were solitary and 17 multifocal. The age at presentation ranged from newborn to 70 years. All multifocal myofibromas and 91% of solitary myofibromas occurred in children. The head and neck region was the most common site (n = 43), followed by the trunk (n = 24), lower limbs (n = 14), upper limbs (n = 11), and viscera (n = 4). Solitary and multifocal myofibromas stained positively for smooth muscle actin (SMA) in 95% and 92% of cases, muscle-specific actin (MSA) in 75% and 50% of cases, and desmin in 10% and 14% of cases, respectively. Regressive features were seen in 34 solitary myofibromas and in nine multifocal myofibromas. Most patients were treated with complete excision (n = 79) or partial excision (n = 12). There were no recurrences after treatment.
CONCLUSIONS:
  Solitary and multiple myofibromas are benign tumours that predominantly occur in infancy and childhood. Myofibromas occur especially in the head and neck region, and are characterized by SMA and, to a lesser extent, MSA expression. The clinical course is self-limiting, and local excision appears to be sufficient.
AuthorsLindsey Oudijk, Michael A den Bakker, Wim C J Hop, Marta Cohen, Adrian K Charles, Rita Alaggio, Cheryl M Coffin, Ronald R de Krijger
JournalHistopathology (Histopathology) Vol. 60 Issue 6B Pg. E1-11 (May 2012) ISSN: 1365-2559 [Electronic] England
PMID22486319 (Publication Type: Journal Article)
Copyright© 2012 Blackwell Publishing Ltd.
Chemical References
  • Biomarkers, Tumor
Topics
  • Biomarkers, Tumor (metabolism)
  • Child
  • Child, Preschool
  • Female
  • Head and Neck Neoplasms (pathology)
  • Humans
  • Immunohistochemistry
  • Infant
  • Infant, Newborn
  • Male
  • Myofibroma (pathology)

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