Sinensetin attenuates LPS-induced inflammation by regulating the protein level of IκB-α.

Abstract

Sinensetin is one of the polymethoxyflavones (PMFs) having five methoxy groups on the basic benzo-γ-pyrone skeleton with a carbonyl group at the C(4) position. We investigated in this study the anti-inflammatory activity of sinensetin in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. Sinensetin showed anti-inflammatory activity by regulating the protein level of inhibitor κB-α (IκB-α).

• Authors: Hye-Sun Shin, Seong-Il Kang, Seon-A Yoon, Hee-Chul Ko, Se-Jae Kim
• Journal: Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 76 Issue 4 Pg. 847-9 ( 2012) ISSN: 1347-6947 [Electronic] England
• PMID: 22484952 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Flavonoids
• I-kappa B Proteins
• Interleukin-1beta
• Interleukin-6
• Lipopolysaccharides
• Nfkbia protein, mouse
• NF-KappaB Inhibitor alpha
• sinensetin

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
• Cell Line
• Dose-Response Relationship, Drug
• Flavonoids (pharmacology)
• Gene Expression (drug effects)
• I-kappa B Proteins (genetics, metabolism)
• Inflammation (drug therapy, immunology, metabolism)
• Interleukin-1beta (biosynthesis, immunology)
• Interleukin-6 (biosynthesis, immunology)
• Lipopolysaccharides (antagonists & inhibitors, pharmacology)
• Macrophages (drug effects, immunology, metabolism)
• Mice
• NF-KappaB Inhibitor alpha