Cytotoxic cytochalasins from the endozoic fungus Phoma sp. of the giant jellyfish Nemopilema nomurai.

Abstract

Four new cytochalasin derivatives (1-4), together with cytochalasin B (5), were isolated from the fungus Phoma sp. obtained from the giant jellyfish Nemopilema nomurai. The planar structure and relative stereochemistry were established by analysis of 1D and 2D NMR data. The absolute configuration was defined by the modified Mosher's method. The compounds showed significant cytotoxicity against a small panel of human solid tumor cell lines (A549, SK-OV-3, SK-MEL-2, XF 498, and HCT15) with IC(50) values in the range of 0.5-30 μM. The cytochalasin B (5) showed obvious cytotoxicity with IC(50) of 7.9 μM against HeLa human cervical carcinoma cells.

• Authors: Eun La Kim, Jian Lin Li, Hung The Dang, Jongki Hong, Chong-Ok Lee, Dong-Kyoo Kim, Won Duk Yoon, Euikyung Kim, Yonghong Liu, Jee H Jung
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 22 Issue 9 Pg. 3126-9 (May 01 2012) ISSN: 1464-3405 [Electronic] England
• PMID: 22483395 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents
• Cytochalasins

Topics

• Animals
• Antineoplastic Agents (chemistry)
• Ascomycota (chemistry)
• Cell Death (drug effects)
• Cell Line, Tumor
• Cytochalasins (chemistry, pharmacology)
• Dose-Response Relationship, Drug
• Early Detection of Cancer
• Humans
• Inhibitory Concentration 50
• Molecular Structure
• Scyphozoa (microbiology)