Melorheostosis and its treatment with intravenous zoledronic acid.

Abstract

We report a case of melorheostosis, a rare bone disorder characterised by mesodermal dysplasia, and its successful and prolonged treatment with the intravenous bisphosphonate zoledronic acid. The middle-aged man presented with pain and swelling of his tibia, which was diagnosed by imaging and bone biopsy as being due to melorheostosis. There was early symptom control after a single infusion of intravenous zoledronic acid. Prolonged symptom relief was accompanied by long-term suppression of the bone resorption marker β cross-laps. We suggest that melorheostosis can be treated with intravenous zoledronic acid and that treatment can be monitored by the use of a specific bone resorption marker.

• Authors: Rosemary Jane Hollick, Alison Black, David Reid
• Journal: BMJ case reports (BMJ Case Rep) Vol. 2010 ( 2010) ISSN: 1757-790X [Electronic] England
• PMID: 22479293 (Publication Type: Journal Article)