Abstract |
Povidone-iodine is most commonly used worldwide because of its germicidal activity, relatively low irritancy or toxicity and low cost. Frequently, povidone-iodine is used as a topical antiseptic for treating and preventing wound infection. In rare cases skin irritation or iododerma-like eruption could represent possible adverse effects due to the oxidative effects of iodine and allergic hypersensitivity reaction. In this report we describe a case of a massive adverse reaction to the irrigation of surgical wound dehiscence with 10 percent povidone-iodine solution after deep-impacted, lower third molar extraction. This reaction was related to a central neurotrophic reflex involving three trigeminal branches and probably due to peripheral chemical insult of mandible nerve. This adverse reaction determined a severe edema and diffuse skin lesions, involving the whole left side of the face mimicking an iododerma-like eruption. These violent symptoms were solved after 60 days. Furthermore, we report a small permanent skin scar in the zygomatic area and transient alterations of facial sensitivity on the affected side which completely disappeared in 6 months.
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Authors | G Sammartino, M Tia, S Tete, L Perillo, O Trosino |
Journal | Journal of biological regulators and homeostatic agents
(J Biol Regul Homeost Agents)
2012 Jan-Mar
Vol. 26
Issue 1
Pg. 145-9
ISSN: 0393-974X [Print] Italy |
PMID | 22475107
(Publication Type: Case Reports, Letter)
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Chemical References |
- Anti-Infective Agents, Local
- Povidone-Iodine
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Topics |
- Adult
- Anti-Infective Agents, Local
(adverse effects)
- Humans
- Male
- Molar, Third
(surgery)
- Povidone-Iodine
(adverse effects)
- Surgical Wound Dehiscence
(complications)
- Therapeutic Irrigation
(adverse effects, methods)
- Tooth Extraction
(adverse effects)
- Tooth, Impacted
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