Abstract | BACKGROUND: OBJECTIVE: METHODS: MEDLINE (1950-November 2011), EMBASE (1990-November 2011), and Cochrane Central Register of Controlled Trials (indexed September 2011) were systematically searched. A manual search of references from reports of clinical trials and review articles was performed to identify additional relevant studies. Randomized controlled trials 12 weeks or more in duration evaluating any of the oral antidiabetic drugs and studying regression from prediabetes to normoglycemia were included. A random-effects model was used to calculate pooled odds ratios with 95% confidence intervals. RESULTS: Thirteen studies (N = 11,600 participants) were included in the meta-analysis. Use of oral antidiabetic drugs in prediabetic patients was shown to double the odds of achieving normoglycemia compared to controls (OR 2.03, 95% CI 1.54 to 2.67). When individual classes of oral antidiabetic drugs were evaluated, use of thiazolidinediones (OR 2.33, 95% CI 1.93 to 2.81) and α- glucosidase inhibitors (OR 2.02, 95% CI 1.26 to 3.24) was associated with significantly increased odds. However, biguanides (OR 2.04) and sulfonylureas (OR 1.84) failed to reach statistical significance (p = 0.06 and p = 0.39, respectively). CONCLUSIONS:
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Authors | Olivia J Phung, William L Baker, Vanita Tongbram, Adarsh Bhardwaj, Craig I Coleman |
Journal | The Annals of pharmacotherapy
(Ann Pharmacother)
Vol. 46
Issue 4
Pg. 469-76
(Apr 2012)
ISSN: 1542-6270 [Electronic] United States |
PMID | 22474136
(Publication Type: Journal Article, Meta-Analysis, Review)
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Chemical References |
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Topics |
- Administration, Oral
- Diabetes Mellitus, Type 2
(prevention & control)
- Humans
- Hypoglycemic Agents
(administration & dosage, pharmacology, therapeutic use)
- Models, Statistical
- Prediabetic State
(drug therapy)
- Randomized Controlled Trials as Topic
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