Abstract | BACKGROUND AND PURPOSE: METHODS: Patients were grouped according to vessel status (Thrombolysis In Myocardial Infarction [TIMI] grade) for logistic regression of clinical response, applying the data from DIAS-2 as well as the pooled data from DIAS, DEDAS, and DIAS-2. RESULTS: In DIAS-2, a substantial number of mismatch-selected patients (126/179; 70%) presented with a normal flow/low-grade stenosis (TIMI 2-3) at screening, with the majority having a favorable outcome at day 90. In contrast, favorable outcome rates in patients with vessel occlusion/high-grade stenosis (TIMI 0-1) were 18% with placebo versus 36% and 27% with desmoteplase 90 and 125 μg/kg, respectively. The clinical effect based on the pooled data from DIAS, DEDAS, and DIAS-2 was favorable for desmoteplase-treated patients presenting with TIMI 0 to 1 at baseline (OR, 4.144; 95% CI, 1.40-12.23; P=0.010). There was no desmoteplase treatment benefit in patients presenting with TIMI 2 to 3 (OR, 1.109). CONCLUSIONS: In this sample of patients with a mismatch diagnosed, proximal vessel occlusion or severe stenosis was associated with clinically beneficial treatment effects of desmoteplase. Selecting patients using CTA or MRA in clinical trials of thrombolytic therapy is justifiable.
|
Authors | Jochen B Fiebach, Yasir Al-Rawi, Max Wintermark, Anthony J Furlan, Howard A Rowley, Annika Lindstén, Jamal Smyej, Paul Eng, Steven Warach, Salvador Pedraza |
Journal | Stroke
(Stroke)
Vol. 43
Issue 6
Pg. 1561-6
(Jun 2012)
ISSN: 1524-4628 [Electronic] United States |
PMID | 22474060
(Publication Type: Clinical Trial, Phase II, Clinical Trial, Phase III, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Fibrinolytic Agents
- salivary plasminogen activator alpha 1, Desmodus rotundus
- Plasminogen Activators
|
Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Brain Ischemia
(drug therapy, physiopathology)
- Constriction, Pathologic
(drug therapy, physiopathology)
- Female
- Fibrinolytic Agents
(administration & dosage, adverse effects)
- Humans
- Male
- Middle Aged
- Plasminogen Activators
(administration & dosage, adverse effects)
- Stroke
(drug therapy, physiopathology)
|