Management of EGFR-inhibitor associated rash: a retrospective study in 49 patients.

In recent years inhibitors directed against the epidermal growth factor receptor (EGFR) have evolved as effective targeting cancer drugs. Characteristic papulopustular exanthemas, often described as acneiform rashes, are the most frequent adverse effect associated with this class of novel cancer drugs and develop in > 90% of patients. Notably, the rash may significantly compromise the patients' quality of life, thereby potentially leading to incompliance as well as dose reduction or even termination of the anti-EGFR therapy. Yet, an effective dermatologic management of cutaneous adverse effects can be achieved. Whereas various case reports, case series or expert opinions on the management of EGFR-inhibitor (EGFRI) induced rashes have been published, data on systematic management studies are sparse.
Here, we present a retrospective, uncontrolled, comparative study in 49 patients on three established regimens for the management of EGFRI-associated rashes.
Strikingly, patients' rash severity improved significantly over three weeks of treatment with topical mometason furoate cream, topical prednicarbate cream plus nadifloxacin cream, as well as topical prednicarbate cream plus nadifloxacin cream plus systemic isotretinoin.
In summary our results demonstrate that EGFRI-associated rashes can be effectively managed by specific dermatologic interventions. Whereas mild to moderate rashes should be treated with basic measures in combination with topical glucocorticosteroids or combined regiments using glucocorticosteroids and antiseptics/antibiotics, more severe or therapy-resistant rashes are likely to respond with the addition of systemic retinoids.
AuthorsPeter Arne Gerber, Stephan Meller, Tatiana Eames, Bettina Alexandra Buhren, Holger Schrumpf, Sonja Hetzer, Laura Maximiliane Ehmann, Wilfried Budach, Edwin Bölke, Christiane Matuschek, Andreas Wollenberg, Bernhard Homey
JournalEuropean journal of medical research (Eur J Med Res) Vol. 17 Pg. 4 ( 2012) ISSN: 2047-783X [Electronic] England
PMID22472354 (Publication Type: Journal Article)
Chemical References
  • Fluoroquinolones
  • Pregnadienediols
  • Protein Kinase Inhibitors
  • Quinolizines
  • Mometasone Furoate
  • nadifloxacin
  • EGFR protein, human
  • Receptor, Epidermal Growth Factor
  • Isotretinoin
  • Administration, Topical
  • Exanthema (chemically induced, drug therapy, pathology)
  • Fluoroquinolones (administration & dosage)
  • Humans
  • Isotretinoin (administration & dosage)
  • Mometasone Furoate
  • Pregnadienediols (administration & dosage)
  • Protein Kinase Inhibitors (therapeutic use, toxicity)
  • Quinolizines (administration & dosage)
  • Receptor, Epidermal Growth Factor (antagonists & inhibitors)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: