Abstract | BACKGROUND: METHODS: Sixteen male Wistar rats weighing approximately 200 g were used. Twelve rats were treated with NTS via the tail vein and divided into 3 groups (groups A, B, and C). Another 4 rats treated with saline served as controls (group D). DHA-TG and soybean oil emulsions were intraperitoneally administered to the rats in groups A and B, respectively, 24 h prior to NTS injection, and 0, 1, 2, 3, 4, and 5 days after the injection. Saline was administered to the rats in groups C and D in the same manner. All rats were sacrificed on day 6 to obtain plasma and kidney samples. Analyses of urinary protein levels and fatty acid composition of plasma and kidney as well as histological examination of the kidneys were performed. RESULTS: Urinary protein levels in group A were significantly lower than those in group C (35.0 ± 13.3 vs. 79.2 ± 11.8 mg/day on day 5, means ± SE, p < 0.05). DHA levels in the PL fraction of the kidneys in group A were significantly increased compared with those in groups B and C. CONCLUSIONS: These results suggest that the DHA-TG emulsion may have beneficial effects on NTS nephritis in the rat.
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Authors | Norio Nakamura, Ryuichiro Kumasaka, Lu Yong Fu, Takeshi Fujita, Reiichi Murakami, Michiko Shimada, Yuko Shimaya, Hiroshi Osawa, Hideaki Yamabe, Ken Okumura, Kei Hamazaki, Tomohito Hamazaki |
Journal | Nephron extra
(Nephron Extra)
Vol. 1
Issue 1
Pg. 139-46
(Jan 2011)
ISSN: 1664-5529 [Electronic] Switzerland |
PMID | 22470387
(Publication Type: Journal Article)
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