ESH position paper: renal denervation - an interventional therapy of resistant hypertension.

Abstract

Experts from the European Society of Hypertension prepared this position paper in order to summarize current evidence, unmet needs and practical recommendations on the application of percutaneous transluminal ablation of renal nerves [renal denervation (RDN)] as a novel therapeutic strategy for the treatment of resistant hypertension. The sympathetic nervous activation to the kidney and the sensory afferent signals to the central nervous system represent the targets of RND. Clinical studies have documented that catheter-based RDN decreases both efferent sympathetic and afferent sensory nerve traffic leading to clinically meaningful systolic and diastolic blood pressure (BP) reductions in patients with resistant hypertension. This position statement intends to facilitate a better understanding of the effectiveness, safety, limitations and issues still to be addressed with RDN.

• Authors: Roland E Schmieder, Josep Redon, Guido Grassi, Sverre E Kjeldsen, Giuseppe Mancia, Krzysztof Narkiewicz, Gianfranco Parati, Luis Ruilope, Philippe van de Borne, Costas Tsioufis
• Journal: Journal of hypertension (J Hypertens) Vol. 30 Issue 5 Pg. 837-41 (May 2012) ISSN: 1473-5598 [Electronic] Netherlands
• PMID: 22469838 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Aged
• Cardiology (methods)
• Catheter Ablation (methods)
• Denervation (methods)
• Diastole
• Europe
• Humans
• Hypertension (therapy)
• Kidney (innervation)
• Middle Aged
• Neurosurgical Procedures (methods)
• Randomized Controlled Trials as Topic
• Renal Artery (innervation)
• Societies, Medical
• Sympathetic Nervous System
• Systole
• Treatment Outcome