Identification of risk factors for chronic Q fever, the Netherlands.

Abstract

Since 2007, the Netherlands has experienced a large Q fever outbreak. To identify and quantify risk factors for development of chronic Q fever after Coxiella burnetii infection, we performed a case-control study. Comorbidity, cardiovascular risk factors, medications, and demographic characteristics from 105 patients with proven (n = 44), probable (n = 28), or possible (n = 33) chronic Q fever were compared with 201 patients who had acute Q fever in 2009 but in whom chronic Q fever did not develop (controls). Independent risk factors for development of proven chronic Q fever were valvular surgery, vascular prosthesis, aneurysm, renal insufficiency, and older age.

• Authors: Linda M Kampschreur, Sandra Dekker, Julia C J P Hagenaars, Peter J Lestrade, Nicole H M Renders, Monique G L de Jager-Leclercq, Mirjam H A Hermans, Cornelis A R Groot, Rolf H H Groenwold, Andy I M Hoepelman, Peter C Wever, Jan Jelrik Oosterheert
• Journal: Emerging infectious diseases (Emerg Infect Dis) Vol. 18 Issue 4 Pg. 563-70 (Apr 2012) ISSN: 1080-6059 [Electronic] United States
• PMID: 22469535 (Publication Type: Journal Article)

Topics

• Adult
• Age Factors
• Aneurysm (complications)
• Area Under Curve
• Cardiac Surgical Procedures (adverse effects)
• Case-Control Studies
• Disease Outbreaks
• Humans
• Multivariate Analysis
• Neoplasms (complications)
• Netherlands
• Q Fever (epidemiology, etiology)
• Renal Insufficiency (complications)
• Risk Factors
• Young Adult