Lornoxicam.

Abstract

A comprehensive profile on lornoxicam, the oxicam nonsteroidal anti-inflammatory agent which is used in the muscular skeletal and joint disorders such as osteoarthritis and rheumatoid arthritis, is prepared. This profile contains the following sections: description, uses and applications, methods of preparation, physical characteristics, methods of analysis, mechanism of action, pharmacokinetics, reviews, and stability. The physical characteristics section includes ionization constant, solubility, partition coefficient, thermal methods of analysis. X-ray powder diffraction pattern, crystal structure, ultraviolet spectroscopy, vibrational spectroscopy, proton and carbon-13 nuclear magnetic resonance spectrometry, and mass spectrometry. Methods of analysis section includes spectrophotometry, polarography, and chromatography (TLC, HPLC, HPLC-MS).

• Authors: Mahrous O Ahmed, Abdullah A Al-Badr
• Journal: Profiles of drug substances, excipients, and related methodology (Profiles Drug Subst Excip Relat Methodol) Vol. 36 Pg. 205-39 ( 2011) ISSN: 1871-5125 [Print] Netherlands
• PMID: 22469263 (Publication Type: Journal Article)
• Copyright: Copyright © 2011 Elsevier Inc. All rights reserved.