Melan-A/Mart-1- or HMB-45-positive melanocytes are not present in calcifying cystic odontogenic tumors (calcifying odontogenic cysts): a study in 13 Caucasian patients.

Abstract

Melanin pigment and melanocytes may be found in odontogenic cysts and tumors, particularly calcifying cystic odontogenic tumor (CCOT). In the present study we investigated the immunohistochemical expression of the Melan-A/Mart-1 and HMB-45 antigens in 13 Caucasians patients with CCOT. Melan-A/Mart-1- and HMB-45-positive melanocytes were not seen in any of the cases. Our findings are in agreement with the assumption that pigmentation in odontogenic lesions may be a racial phenomenon.

• Authors: Konstantinos I Tosios, Nikolaos Prountzos, Nikolaos Katsoulas, Ioannis G Koutlas, Alexandra Sklavounou-Andrikopoulou
• Journal: Journal of oral science (J Oral Sci) Vol. 54 Issue 1 Pg. 33-8 (Mar 2012) ISSN: 1880-4926 [Electronic] Japan
• PMID: 22466884 (Publication Type: Journal Article)

Chemical References

• MART-1 Antigen
• Melanins
• Melanoma-Specific Antigens
• PMEL protein, human
• gp100 Melanoma Antigen

Topics

• Adolescent
• Adult
• Case-Control Studies
• Child
• Female
• Humans
• Jaw Neoplasms (ethnology, genetics, metabolism, pathology)
• MART-1 Antigen (biosynthesis, genetics)
• Male
• Melanins (genetics)
• Melanocytes (metabolism)
• Melanoma-Specific Antigens (biosynthesis, genetics)
• Middle Aged
• Odontogenic Cyst, Calcifying (ethnology, metabolism, pathology)
• White People (genetics)
• Young Adult
• gp100 Melanoma Antigen