Thirty swines were randomly divided into two groups, with 15 swines in each group. CA model was reproduced by
asphyxia as a result of clamping the trachea, and CC-
CPR and ALC-
CPR was conducted in two groups, respectively. Electrocardiogram (ECG), pulse oxygen saturation [SpO(2)], end-tidal partial pressure of
carbon dioxide [P(ET)CO(2)], aorta systolic blood pressure (SBP), diastolic blood pressure (DBP), central venous pressure (CVP), and tidal volume (VT) were monitored continuously from 10 minutes before
asphyxia to the end of experiment. The aorta mean arterial pressure (MAP), coronary perfusion pressure (
CPP) and minute ventilation (MV) were calculated. Artery blood samples were collected to determine the blood gas analysis
at 10 minutes before
asphyxia, 10 minutes after
asphyxia, and 5, 10, 20 minutes after
resuscitation. The restoration of spontaneous circulation (ROSC) rate, 24-hour survival rate and 24-hour neurological function score were observed.
RESULTS: There were no significant differences in all mentioned indexes between two groups
at 10 minutes before and 10 minutes after
asphyxia. At 2 minutes after the
resuscitation, the MAP (mm Hg, 1 mm Hg = 0.133 kPa) and
CPP (mm Hg) in CC-
CPR group were significantly higher than those in ALC-
CPR group (MAP: 43.60 ± 12.91 vs. 33.40 ± 6.59, P < 0.05;
CPP: 21.67 ± 11.28 vs. 11.80 ± 4.16, P < 0.01), the VT (ml) and MV (L/min)in ALC-
CPR group were significantly higher than those in CC-
CPR group (VT: 111.67 ± 18.12 vs. 56.60 ± 7.76; MV: 11.17 ± 1.81 vs. 5.54 ± 0.79, both P < 0.01). At 5, 10, 20 minutes after
resuscitation, in ALC-
CPR group, pH value, arterial partial pressure of
oxygen [PaO(2), mm Hg] and arterial oxygen saturation [SaO(2)] were increased, and HCO(3)(-) (mmol/L) and base excess (BE, mmol/L) were decreased, which significantly higher than those in CC-
CPR group [pH at 20 minutes after
resuscitation: 7.16 ± 0.16 vs. 7.01 ± 0.14; PaO(2): 82.73 ± 13.20 vs. 58.33 ± 17.77; HCO(3)(-): 27.71 ± 3.11 vs. 21.04 ± 3.62; BE: -4.78 ± 4.30 vs. -10.23 ± 2.12; SaO(2): 0.893 ± 0.088 vs. 0.764 ± 0.122], and arterial partial pressure of
carbon dioxide [PaCO(2), mm Hg], K(+) (mmol/L) and
lactic acid (Lac,mmol/L) were significantly lower than those in CC-
CPR group [PaCO(2) at 20 minutes after
resuscitation: 49.40 ± 15.60 vs. 79.80 ± 15.35; K(+): 7.18 ± 1.76 vs. 8.55 ± 1.02; Lac: 8.17 ± 1.46 vs. 10.39 ± 1.92], with statistical significant (P < 0.05 or P < 0.01). But the ROSC rate and 24-hour survival rate in ALC-
CPR group were significantly higher than those in CC-
CPR group (ROSC rate: 80.0% vs. 26.7%, P < 0.01; 24-hour survival rate: 60.0% vs. 13.3%, P < 0.05), and the 24-hour neurological function score was significantly lower than that in CC-
CPR group (1.11 ± 0.33 vs. 3.50 ± 0.70, P < 0.01).
CONCLUSION: