Abstract | BACKGROUND:
Radiotherapy, a cornerstone of head and neck cancer treatment, causes substantial morbidity to normal adjoining bone. The authors assessed the radioprotective effect of amifostine therapy on the mineralization of the mandible using micro-computed tomography. They hypothesized that amifostine would safeguard the mandible from radiation-induced disruption of the mineralization process and the associated failure of new bone creation. METHODS: Male Sprague-Dawley rats were randomized into three groups: control (n = 8), radiation therapy (n = 5), and amifostine (n = 8). Animals in the radiation therapy and amifostine groups underwent human bioequivalent radiation of 70 Gy in five fractions to the left hemimandible. Fifty-six days after irradiation, the hemimandibles were harvested for radiomorphometric analyses. RESULTS: CONCLUSIONS: The authors have successfully demonstrated the ability of amifostine pretreatment to protect the natural mineralization profile of bone. This reflects the capacity of amifostine prophylaxis to safeguard the normal surrounding mandible from the impediments of collateral damage imposed by irradiation. Further study can correlate these findings with the potential use of amifostine to prevent the devastating associated morbidities of radiotherapy such as pathologic fractures and osteoradionecrosis.
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Authors | Catherine N Tchanque-Fossuo, Alexis Donneys, Sagar S Deshpande, Noah S Nelson, Matt J Boguslawski, K Kelly Gallagher, Deniz Sarhaddi, Behdod Poushanchi, Steven A Goldstein, Steven R Buchman |
Journal | Plastic and reconstructive surgery
(Plast Reconstr Surg)
Vol. 129
Issue 4
Pg. 646e-655e
(Apr 2012)
ISSN: 1529-4242 [Electronic] United States |
PMID | 22456378
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Radiation-Protective Agents
- Amifostine
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Topics |
- Amifostine
(pharmacology)
- Animals
- Calcification, Physiologic
(drug effects, radiation effects)
- Male
- Mandible
(diagnostic imaging, drug effects, pathology, radiation effects)
- Microradiography
- Radiation Dosage
- Radiation Injuries, Experimental
(prevention & control)
- Radiation-Protective Agents
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Tomography, X-Ray Computed
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