HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Proteinase-activated receptors (PARs) and calcium signaling in cancer.

Abstract
Proteinase activated receptors (PARs), a small subfamily of G protein-coupled receptors with four members, PAR₁, PAR₂, PAR₃ and PAR₄, are expressed in various tumours from epithelial origin and can play an important role in tumour progression and metastasis. Within the complex intracellular PAR signaling networks triggered by PARs, an elevation in intracellular free calcium ion concentrations represents a key second messenger system. In this review, we summarize current information about the mechanisms whereby PARs can signal via intracellular calcium in the setting of cancer and we discuss possibilities for using the PAR-[Ca(2+)](i) signaling pathway as a target for the therapy of epithelial cancer.
AuthorsRoland Kaufmann, Morley D Hollenberg
JournalAdvances in experimental medicine and biology (Adv Exp Med Biol) Vol. 740 Pg. 979-1000 ( 2012) ISSN: 0065-2598 [Print] United States
PMID22453980 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Receptors, Proteinase-Activated
Topics
  • Animals
  • Calcium Signaling (physiology)
  • Humans
  • MAP Kinase Signaling System
  • Neoplasms (metabolism, therapy)
  • Receptors, Proteinase-Activated (physiology)
  • Signal Transduction
  • Tumor Microenvironment

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: