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Daily variation in the concentration of melatonin and 5-methoxytryptophol in the human pineal gland: effect of age and Alzheimer's disease.

Abstract
Melatonin and 5-methoxytryptophol (ML) were measured in human pineals (38 controls, 16 subjects with Alzheimer's disease). Time of death had a major influence on the indole concentrations with significantly higher melatonin levels occurring at night (22.00-10.00 h) and significantly higher ML levels occurring during the day (10.00-22.00 h). This daily variation disappeared in both the older subjects (55-92 years) and in the Alzheimer patients (55-89 years).
AuthorsD J Skene, B Vivien-Roels, D L Sparks, J C Hunsaker, P Pévet, D Ravid, D F Swaab
JournalBrain research (Brain Res) Vol. 528 Issue 1 Pg. 170-4 (Sep 24 1990) ISSN: 0006-8993 [Print] Netherlands
PMID2245336 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Indoles
  • methoxytryptophol
  • Melatonin
Topics
  • Adolescent
  • Adult
  • Aged
  • Aging (metabolism)
  • Alzheimer Disease (metabolism)
  • Circadian Rhythm
  • Female
  • Humans
  • Indoles (metabolism)
  • Male
  • Melatonin (metabolism)
  • Middle Aged
  • Osmolar Concentration
  • Pineal Gland (metabolism)
  • Radioimmunoassay
  • Sex Characteristics

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