Abstract |
Melatonin and 5-methoxytryptophol (ML) were measured in human pineals (38 controls, 16 subjects with Alzheimer's disease). Time of death had a major influence on the indole concentrations with significantly higher melatonin levels occurring at night (22.00-10.00 h) and significantly higher ML levels occurring during the day (10.00-22.00 h). This daily variation disappeared in both the older subjects (55-92 years) and in the Alzheimer patients (55-89 years).
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Authors | D J Skene, B Vivien-Roels, D L Sparks, J C Hunsaker, P Pévet, D Ravid, D F Swaab |
Journal | Brain research
(Brain Res)
Vol. 528
Issue 1
Pg. 170-4
(Sep 24 1990)
ISSN: 0006-8993 [Print] Netherlands |
PMID | 2245336
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Indoles
- methoxytryptophol
- Melatonin
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Topics |
- Adolescent
- Adult
- Aged
- Aging
(metabolism)
- Alzheimer Disease
(metabolism)
- Circadian Rhythm
- Female
- Humans
- Indoles
(metabolism)
- Male
- Melatonin
(metabolism)
- Middle Aged
- Osmolar Concentration
- Pineal Gland
(metabolism)
- Radioimmunoassay
- Sex Characteristics
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