Abstract |
We evaluated ceftobiprole against the well-characterized Enterococcus faecalis strain OG1RF (with and without the β-lactamase [Bla] plasmid pBEM10) in a murine urinary tract infection (UTI) model. Ceftobiprole was equally effective for Bla(+) and Bla(-) OG1 strains, while ampicillin was moderately to markedly (depending on the inoculum) less effective against Bla(+) than Bla(-) OG1 strains. These data illustrate an in vivo effect on ampicillin of Bla production by E. faecalis and the stability and efficacy of ceftobiprole in experimental UTI.
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Authors | Kavindra V Singh, Barbara E Murray |
Journal | Antimicrobial agents and chemotherapy
(Antimicrob Agents Chemother)
Vol. 56
Issue 6
Pg. 3457-60
(Jun 2012)
ISSN: 1098-6596 [Electronic] United States |
PMID | 22450988
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Cephalosporins
- ceftobiprole
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Topics |
- Animals
- Anti-Bacterial Agents
(therapeutic use)
- Cephalosporins
(therapeutic use)
- Enterococcus faecalis
(drug effects, pathogenicity)
- Mice
- Urinary Tract Infections
(drug therapy, microbiology)
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