Drugs for tuberculosis.

Abstract

RECOMMENDATIONS:

The standard treatment for latent tuberculosis is nine months of isoniazid taken daily, or twice weekly under direct observation by a healthcare worker. Taking isoniazid and rifapentine once weekly for 12 weeks under direct observation is an alternative for patients >12 years old. Initial therapy for patients with active or suspected tuberculosis should include isoniazid, rifampin,pyrazinamide and ethambutol until susceptibility is known. In patients with drug-susceptible pulmonary tuberculosis, the continuation phase of treatment should be a combination of isoniazid and either rifampin or rifapentine, taken for 4 or 7 months depending on risk factors. Confirmed multidrug-resistant tuberculosis or extensively drug-resistant tuberculosis should be treated with directly observed therapy in collaboration with a clinician familiar with management of these conditions. Treatment must include at least 4 drugs to which the organism is susceptible; the duration of therapy should usually be 18-24 months. Directly observed therapy by a healthcare worker should be offered to all patients with active tuberculosis to minimize treatment failure, relapse and the emergence of drug resistance.

• Journal: Treatment guidelines from the Medical Letter (Treat Guidel Med Lett) Vol. 10 Issue 116 Pg. 29-36; quiz 37-8 (Mar 2012) ISSN: 1541-2792 [Electronic] United States
• PMID: 22450707 (Publication Type: Journal Article, Review)

Chemical References

• Antitubercular Agents

Topics

• AIDS-Related Opportunistic Infections (drug therapy)
• Antitubercular Agents (administration & dosage, adverse effects, therapeutic use)
• Drug Administration Schedule
• Drug Resistance, Bacterial
• Humans
• Latent Tuberculosis (drug therapy)
• Tuberculosis (drug therapy)
• Tuberculosis, Multidrug-Resistant (drug therapy)