Abstract | BACKGROUND & OBJECTIVES: METHODS: Male OXYS and Wistar (control) rats were randomized across four experimental groups (n=15), which received 1.26 mg GA, 0.84 mg ALN, or 1.26 mg GA + 5.06 mg DHQ per kg of body weight. Untreated rats were used as control groups. At the end of treatment, the bone mineral density (BMD), bone biomechanical properties, and the levels of serum osteocalcin, αC-terminal crosslinked telopeptides of type I collagen (α-CTx) and calcium were measured. RESULTS: All treatments increased BMD in rats of both strains, but the improvement was more pronounced in OXYS rats: GA+DHQ increased both the strength of the femur by 20 per cent (P<0.01) and BMD by 7.6 per cent (P<0.023). GA+DHQ and ALN reduced serum α-CTx in OXYS rats. Only GA increased the level of osteocalcin in OXYS rats (P<0.05). ALN increased the cross-sectional area of the femur by 9 per cent (P<0.04) in OXYS and by 12 per cent (P<0.05) in Wistar rats. INTERPRETATION & CONCLUSIONS: The combined treatment with GA+DHQ appears to be more effective at maintaining strength of the femur and BMD in OXYS rats, when compared to the individual drugs GA and ALN.
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Authors | Natalya A Muraleva, Evgeniy N Ofitserov, Vladimir P Tikhonov, Natalya G Kolosova |
Journal | The Indian journal of medical research
(Indian J Med Res)
Vol. 135
Pg. 221-7
( 2012)
ISSN: 0971-5916 [Print] India |
PMID | 22446865
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Bone Density Conservation Agents
- Collagen Type I
- Collagen Type I, alpha 1 Chain
- Osteocalcin
- Quercetin
- taxifolin
- Glucosamine
- Calcium
- Alendronate
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Topics |
- Alendronate
(administration & dosage, adverse effects)
- Animals
- Bone Density
(drug effects)
- Bone Density Conservation Agents
(administration & dosage)
- Calcium
(blood)
- Collagen Type I
(blood)
- Collagen Type I, alpha 1 Chain
- Drug Synergism
- Glucosamine
(administration & dosage, analogs & derivatives)
- Humans
- Male
- Osteocalcin
(blood)
- Osteoporosis
(drug therapy)
- Quercetin
(administration & dosage, analogs & derivatives)
- Rats
- Rats, Wistar
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