Abstract | BACKGROUND: STUDY OBJECTIVE: METHODS: RESULTS: Thirty-four of 93 patients received at least one PRBC transfusion. The ScvO(2) goal>70% was achieved in 71.9% of the PRBC group and 66.1% of the no-PRBC group (p=0.30). There was no difference in the change in Sequential Organ Failure Assessment (SOFA) score within the first 24 h in the PRBC group vs. the no-PRBC group (8.6-8.3 vs. 5.8-5.6, p=0.85), time to achievement of central venous pressure>8 mm Hg (732 min vs. 465 min, p=0.14), or the use of norepinephrine to maintain mean arterial pressure>65 mm Hg (81.3% vs. 83.8%, p=0.77). CONCLUSIONS: In this study, the transfusion of PRBC was not associated with improved cellular oxygenation, as demonstrated by a lack of improved achievement of ScvO(2)>70%. Also, the transfusion of PRBC was not associated with improved organ function or improved achievement of the other goals of EGDT. Further studies are needed to determine the impact of transfusion of PRBC within the context of early resuscitation of patients with septic shock.
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Authors | Brian M Fuller, Mithil Gajera, Christa Schorr, David Gerber, R Phillip Dellinger, Joseph Parrillo, Sergio Zanotti |
Journal | The Journal of emergency medicine
(J Emerg Med)
Vol. 43
Issue 4
Pg. 593-8
(Oct 2012)
ISSN: 0736-4679 [Print] United States |
PMID | 22445679
(Publication Type: Journal Article)
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Copyright | Copyright © 2012 Elsevier Inc. All rights reserved. |
Chemical References |
- Vasoconstrictor Agents
- Oxygen
- Norepinephrine
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Topics |
- Arterial Pressure
- Central Venous Pressure
- Erythrocyte Transfusion
- Female
- Humans
- Male
- Middle Aged
- Norepinephrine
(therapeutic use)
- Organ Dysfunction Scores
- Oxygen
(blood)
- Retrospective Studies
- Shock, Septic
(blood, physiopathology, therapy)
- Time Factors
- Vasoconstrictor Agents
(therapeutic use)
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