[Mechanism of neuroprotector action of metabolic antihypoxant reamberin in patients with toxicohypoxic encephalopathy].

Abstract

Based on investigation of a group of patients with heavy forms of sharp poisoning by neurotropic substances, it is established that inclusion if antihypoxant reamberin in intensive treatment of toxicohypoxic encephalopathy leads to a decrease in the depth of central nervous system depression. This is manifested by reduced duration of patient stay in coma and decreased total duration of resuscitation treatment. Improvement of the clinical picture is accompanied by a decrease in lipid peroxidation activity, increase in the level of antioxidant enzymes, and decrease in the level of NR2A auto-antibodies. That is objective evidence of the efficiency of neuroprotective therapy by reamberin.

• Authors: G A Livanov, V G Bazarova, B V Batotsyrenov, S A Vasil'ev, S I Glushkov, Kh V Batotsyrenova
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) Vol. 75 Issue 1 Pg. 34-8 ( 2012) ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 22442962 (Publication Type: Controlled Clinical Trial, English Abstract, Journal Article)

Chemical References

• Antioxidants
• Autoantibodies
• Reamberin
• Succinates
• Meglumine

Topics

• Adult
• Antioxidants (therapeutic use)
• Autoantibodies (blood)
• Coma (drug therapy)
• Delirium (drug therapy)
• Female
• Humans
• Hypoxia, Brain (drug therapy)
• Lipid Peroxidation (drug effects)
• Male
• Meglumine (analogs & derivatives, therapeutic use)
• Neurotoxicity Syndromes (drug therapy)
• Succinates (therapeutic use)