For breast cancer prognosis, immunoglobulin kappa chain surfaces to the top.

Abstract

The stromal immunoglobulin kappa chain (IGKC) has been validated as an immunologic biomarker of prognosis and response to therapy in human breast cancer and other cancers. This validation emphasizes the key role of humoral immunity in control of cancer progression and has major implications for determining prognosis of patients with cancer.

• Authors: Theresa L Whiteside, Soldano Ferrone
• Journal: Clinical cancer research : an official journal of the American Association for Cancer Research (Clin Cancer Res) Vol. 18 Issue 9 Pg. 2417-9 (May 01 2012) ISSN: 1557-3265 [Electronic] United States
• PMID: 22442060 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Comment)
• Copyright: ©2012 AACR.

Chemical References

• Biomarkers, Tumor
• IgK
• Immunoglobulins

Topics

• Biomarkers, Tumor (genetics)
• Breast Neoplasms (genetics)
• Carcinoma, Non-Small-Cell Lung (genetics)
• Colorectal Neoplasms (genetics)
• Female
• Gene Expression Profiling
• Humans
• Immunoglobulins (genetics)
• Ovarian Neoplasms (genetics)