Heme in the treatment of heme deficiency states.

Abstract

The mechanism of regulation of heme biosynthesis is of great interest for both biological and medical reasons. The hepatic and erythropoietic porphyrias are shown to be hereditary or acquired disorders characterized by defects in specific enzymes of the heme biosynthetic pathway. In addition, several other diseases can be associated with a defect of heme biosynthesis. Heme has become well established in the treatment of acute porphyrias. In recent years, heme has been used increasingly for the treatment of other heme deficiency states as well.

• Authors: R Tenhunen
• Journal: Scandinavian journal of clinical and laboratory investigation. Supplementum (Scand J Clin Lab Invest Suppl) Vol. 201 Pg. 63-75 ( 1990) ISSN: 0085-591X [Print] Norway
• PMID: 2244185 (Publication Type: Journal Article, Review)

Chemical References

• Heme

Topics

• Anemia, Sideroblastic (drug therapy)
• Heme (deficiency, pharmacokinetics, therapeutic use)
• Humans
• Myelodysplastic Syndromes (drug therapy)
• Porphyrias (drug therapy)