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A β-cyclodextrin, polyethyleneimine and silk fibroin hydrogel containing Centella asiatica extract and hydrocortisone acetate: releasing properties and in vivo efficacy for healing of pressure sores.

AbstractBACKGROUND:
Pressure sores are lesions caused by impaired blood flow. Conventional dressings can absorb exudates, but do not promote wound healing. A hydrogel composed of β-cyclodextrin (β-CD), polyethyleneimine (PEI) and silk fibroin (SF) was assessed for use in healing of pressure sores.
METHODS:
The hydrogel was prepared by crosslinking β-CD-grafted PEI and SF using epichlorohydrin. The gel was then immersed in an aqueous solution of Centella asiatica extract (CAE) 0.7 mg/mL and/or hydrocortisone acetate (HCA) 0.5 mg/mL. The in vivo pressure sore-healing efficacy of the dry gel (with or without the drugs) was investigated in terms of the hyperplasia of epidermis and the number of neutrophils in the skin tissue.
RESULTS:
The specific loading of CAE was 0.0091 g/g of dry gel. The percentage of CAE released at 24 h at pH 3.0, 5.0 and 7.4 was approximately 63.9%, 55.0% and 44.4%, respectively. This pH-dependent release is possibly due to the degree of gel swelling, which decreased with increasing pH. The specific loading of HCA was 0.0050 g/g dry gel, and the percentage release of HCA at 24 h was around 20% at all three pH points. It is likely that HCA release is independent of pH. HCA is a hydrophobic compound, and therefore the release of HCA is affected by the partitioning of HCA between the β-CD cavity and the bulk water phase, but not by the degree of swelling of the hydrogel. The pressure sores treated with the hydrogel healed in 6 days, compared with 10 days for controls.
CONCLUSIONS:
In this study, a β-CD/PEI/SF hydrogel containing CAE and HCA reduced the healing time for pressure sores.
AuthorsM S Lee, S R Seo, J-C Kim
JournalClinical and experimental dermatology (Clin Exp Dermatol) Vol. 37 Issue 7 Pg. 762-71 (Oct 2012) ISSN: 1365-2230 [Electronic] England
PMID22439751 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright© The Author(s). CED © 2012 British Association of Dermatologists.
Chemical References
  • Centella asiatica extract
  • Hydrogels
  • Silk
  • Triterpenes
  • beta-Cyclodextrins
  • hydrocortisone acetate
  • Polyethyleneimine
  • Fibroins
  • Hydrocortisone
Topics
  • Animals
  • Fibroins (therapeutic use)
  • Hydrocortisone (analogs & derivatives, therapeutic use)
  • Hydrogels (chemical synthesis, therapeutic use)
  • Male
  • Mice
  • Mice, Inbred ICR
  • Polyethyleneimine (therapeutic use)
  • Pressure Ulcer (drug therapy)
  • Silk
  • Skin (drug effects)
  • Triterpenes (therapeutic use)
  • Wound Healing (drug effects)
  • beta-Cyclodextrins (therapeutic use)

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