Impact of ingestion of rice bran and shitake mushroom extract on lymphocyte function and cytokine production in healthy rats.
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| Abstract |
This article provides a controlled evaluation of the ability of dietary supplementation with a commercially available rice bran extract modified with shitake mushroom extract (MGN-3) to support the immune function by assessing the ability of immunocytes to proliferate and produce cytokines in response to a mitogenic challenge. Twenty-four male Lewis rats were fed a control diet (Maypo sweetened oatmeal) or Maypo containing the recommended daily dose of MGN-3 for 2 weeks. This treatment modestly enhanced mitogen enhanced proliferation of splenocytes and interferon-gamma (IFN-g) production, and significantly increased proliferation of splenocytes to the superantigen toxic shock syndrome toxin-1 (TSST-1) as well as natural killer (NK) cell activity and production of interleukin-2 (IL-2) by stimulated lymphocytes. These data support the contention that ingestion of MGN-3 can support immune cell function. These data add to a growing body of data showing that ingestion of MGN-3 improves the ability of immune cells to proliferate the lyse tumor cells, suggesting that it may have utility as a dietary aid to support the immune system.
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| Authors | Scott Giese, George Richard Sabell, Mary Coussons-Read |
| Journal | Journal of dietary supplements (J Diet Suppl) Vol. 5 Issue 1 Pg. 47-61 ( 2008) ISSN: 1939-022X [Electronic] England |
| PMID | 22433044 (Publication Type: Journal Article) |
| Chemical References |
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