Synthesis and evaluation of anticancer natural product analogues based on angelmarin: targeting the tolerance towards nutrient deprivation.

Abstract

Inspired by nature: Angelmarin is an anticancer natural product with potent antiausterity activity, that is, selective cytotoxicity towards nutrient-deprived, resistant cancer cells. Through structure-activity relationship studies, three analogues were identified as lead compounds for the develpoment of molecular probes for the investigation of the mode of action and biological targets of the antiausterity compounds.

• Authors: Jakob Magolan, Nathan B P Adams, Hiroko Onozuka, Natasha L Hungerford, Hiroyasu Esumi, Mark J Coster
• Journal: ChemMedChem (ChemMedChem) Vol. 7 Issue 5 Pg. 766-70 (May 2012) ISSN: 1860-7187 [Electronic] Germany
• PMID: 22431333 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Antineoplastic Agents
• Biological Products
• Coumarins
• Plant Extracts
• angelmarin

Topics

• Antineoplastic Agents (chemical synthesis, chemistry, therapeutic use)
• Biological Products (chemistry)
• Cell Line, Tumor
• Cell Survival (drug effects)
• Coumarins (chemical synthesis, chemistry, pharmacology)
• Drug Screening Assays, Antitumor
• Food
• Humans
• Inhibitory Concentration 50
• Molecular Structure
• Pancreatic Neoplasms (drug therapy)
• Plant Extracts (chemical synthesis, chemistry, pharmacology)
• Stereoisomerism
• Stress, Physiological (physiology)
• Structure-Activity Relationship