Abstract | UNLABELLED: BACKGROUND Acotiamide hydrochloride ( acotiamide), a novel selective acetylcholinesterase (AChE) inhibitor, has proven significantly effective in treating functional dyspepsia (FD) in clinical trials, particularly in alleviating meal-related symptoms. In the present study, we examined the gastrointestinal prokinetic effects of acotiamide administered orally or intraduodenally in conscious dogs and investigated in vivo and ex vivo anti-AChE activity of acotiamide to clarify its mechanism of prokinetic action. METHODS: Gastrointestinal motility was measured in conscious dogs with chronically implanted force transducers. KEY RESULTS: CONCLUSIONS & INFERENCES: Our findings revealed that acotiamide administered through the alimentary tract exerts gastroprokinetic action via cholinergic pathways by inhibiting AChE activity. These results may also confirm the mechanism of action in clinical efficacy of acotiamide on FD.
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Authors | K Nagahama, Y Matsunaga, M Kawachi, K Ito, T Tanaka, Y Hori, H Oka, M Takei |
Journal | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
(Neurogastroenterol Motil)
Vol. 24
Issue 6
Pg. 566-74, e256
(Jun 2012)
ISSN: 1365-2982 [Electronic] England |
PMID | 22429221
(Publication Type: Journal Article)
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Copyright | © 2012 Blackwell Publishing Ltd. |
Chemical References |
- Adrenergic alpha-2 Receptor Agonists
- Benzamides
- Cholinesterase Inhibitors
- Thiazoles
- Z 338
- Clonidine
|
Topics |
- Adrenergic alpha-2 Receptor Agonists
(pharmacology)
- Animals
- Benzamides
(pharmacology)
- Cholinesterase Inhibitors
(pharmacology)
- Clonidine
(pharmacology)
- Dogs
- Gastric Emptying
(drug effects)
- Gastrointestinal Motility
(drug effects)
- Gastrointestinal Tract
(drug effects)
- Male
- Thiazoles
(pharmacology)
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