A randomized controlled trial of the GnRH antagonist ganirelix in Chinese normal responders: high efficacy and pregnancy rates.

Abstract

Gonadotropin-releasing hormone (GnRH) antagonists for controlled ovarian stimulation (COS) were only recently introduced into China. The efficacy and safety of the GnRH antagonist ganirelix was assessed in a multicenter, controlled, open-label study, in which Chinese women were randomized to either ganirelix (n = 113) or a long GnRH agonist protocol of triptorelin (n = 120). The primary end point was the amount of recombinant follicle-stimulating hormone (rFSH) required to meet the human chorionic gonadotropin criterion (three follicles ≥17 mm). The amount of rFSH needed was significantly lower for ganirelix (1272 IU) vs. triptorelin (1416 IU; P< 0.001). Ongoing pregnancy rates per started cycle were 39.8% (ganirelix) and 39.2% (triptorelin). Although both treatments were well tolerated, cancellation due to risk of ovarian hyperstimulation syndrome (OHSS) was less frequent with ganirelix (1.8%) than triptorelin (7.5%) (P = 0.06). Less rFSH was needed in the ganirelix protocol than the long GnRH agonist protocol, with fewer reported cases of OHSS and similar pregnancy rates.

• Authors: Jie Qiao, Guangxiu Lu, H W Zhang, Hua Chen, Caihong Ma, Jan I Olofsson, Han Witjes, Esther Heijnen, Bernadette Mannaerts
• Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (Gynecol Endocrinol) Vol. 28 Issue 10 Pg. 800-4 (Oct 2012) ISSN: 1473-0766 [Electronic] England
• PMID: 22429192 (Publication Type: Clinical Trial, Phase III, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Follicle Stimulating Hormone, Human
• Hormone Antagonists
• Recombinant Proteins
• follitropin beta
• Triptorelin Pamoate
• Gonadotropin-Releasing Hormone
• ganirelix

Topics

• Adult
• China (epidemiology)
• Dose-Response Relationship, Drug
• Ectogenesis (drug effects)
• Female
• Fertilization in Vitro
• Follicle Stimulating Hormone, Human (administration & dosage, pharmacology)
• Gonadotropin-Releasing Hormone (adverse effects, agonists, analogs & derivatives, antagonists & inhibitors, pharmacology)
• Hormone Antagonists (adverse effects, pharmacology)
• Humans
• Incidence
• Infertility (therapy)
• Oocyte Retrieval
• Ovarian Hyperstimulation Syndrome (chemically induced, epidemiology, physiopathology, prevention & control)
• Ovary (drug effects, physiopathology)
• Ovulation Induction (adverse effects)
• Pregnancy
• Pregnancy Rate
• Recombinant Proteins (administration & dosage, pharmacology)
• Severity of Illness Index
• Triptorelin Pamoate (adverse effects, pharmacology)
• Young Adult