[High-dosage oral magnesium therapy in arrhythmias. Results of an observational study in 1.160 patients with arrhythmia].

Abstract

In the treatment of cardiac arrhythmias of varying genesis, an "observational study" in 1,160 patients showed that a high-dose oral magnesium preparation (Magnesium-Diasporal N 300 Granulat) was effective. In 82% of the patients observed, a dose of at least 300 mg magnesium/day produced good to very good results. Adverse effects of the drug were observed in only 1.6% of the patients. For all groups, the "success parameters" improved significantly. High-rate arrhythmias showed a better response to magnesium treatment than did low-rate arrhythmias, with a close correlation being found with the heart rate at the start of treatment. High-dose oral magnesium had a positive effect on concomitant hypertension. At a dosage of 300 mg treatment should be continued for at least 6 weeks.

• Authors: H Holzgartner, E Maier, W Vierling
• Journal: Fortschritte der Medizin (Fortschr Med) Vol. 108 Issue 28 Pg. 539-42 (Sep 30 1990) ISSN: 0015-8178 [Print] Germany
• Vernacular Title: Hochdosierte orale Magnesiumtherapie bei Herzrhythmusstörungen. Ergebnisse einer Anwendungsbeobachtung bei 1,160 Patienten mit Arrhythmie.
• PMID: 2242840 (Publication Type: Clinical Trial, Journal Article, Multicenter Study)

Chemical References

• Levulinic Acids
• levulinic acid

Topics

• Adult
• Aged
• Arrhythmias, Cardiac (drug therapy)
• Dose-Response Relationship, Drug
• Female
• Heart Rate (drug effects)
• Humans
• Levulinic Acids (administration & dosage, adverse effects, therapeutic use)
• Male
• Middle Aged