[High-dosage oral magnesium therapy in arrhythmias. Results of an observational study in 1.160 patients with arrhythmia].

In the treatment of cardiac arrhythmias of varying genesis, an "observational study" in 1,160 patients showed that a high-dose oral magnesium preparation (Magnesium-Diasporal N 300 Granulat) was effective. In 82% of the patients observed, a dose of at least 300 mg magnesium/day produced good to very good results. Adverse effects of the drug were observed in only 1.6% of the patients. For all groups, the "success parameters" improved significantly. High-rate arrhythmias showed a better response to magnesium treatment than did low-rate arrhythmias, with a close correlation being found with the heart rate at the start of treatment. High-dose oral magnesium had a positive effect on concomitant hypertension. At a dosage of 300 mg treatment should be continued for at least 6 weeks.
AuthorsH Holzgartner, E Maier, W Vierling
JournalFortschritte der Medizin (Fortschr Med) Vol. 108 Issue 28 Pg. 539-42 (Sep 30 1990) ISSN: 0015-8178 [Print] GERMANY
Vernacular TitleHochdosierte orale Magnesiumtherapie bei Herzrhythmusstörungen. Ergebnisse einer Anwendungsbeobachtung bei 1,160 Patienten mit Arrhythmie.
PMID2242840 (Publication Type: Clinical Trial, English Abstract, Journal Article, Multicenter Study)
Chemical References
  • Levulinic Acids
  • levulinic acid
  • Adult
  • Aged
  • Arrhythmias, Cardiac (drug therapy)
  • Dose-Response Relationship, Drug
  • Female
  • Heart Rate (drug effects)
  • Humans
  • Levulinic Acids (administration & dosage, adverse effects, therapeutic use)
  • Male
  • Middle Aged

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