Risk factors that affect the treatment of interstitial cystitis using intravesical therapy with a dimethyl sulfoxide cocktail.

Abstract

INTRODUCTION AND HYPOTHESIS:

Dimethyl sulfoxide (DMSO) bladder instillation is a standard therapy for interstitial cystitis (IC); however, there are varying degrees of success. We hypothesize that first-line intravesical therapy with a DMSO cocktail will optimize treatment outcome.

METHODS:

Ninety women with newly diagnosed IC were enrolled consecutively for the treatment. The IC symptom and problem index was used as an outcome measure.

RESULTS:

Six (6.7%) patients dropped out of the treatment due to intolerable bladder irritation. Fifty-five (65.5%) of the remaining 84 patients, who completed the treatment, experienced ≧50% symptomatic improvement. After a regression analysis, three clinical variables were found to affect treatment adversely, i.e., the presence of advanced cystoscopic glomerulations, microscopic hematuria, and urodynamic detrusor underactivity, respectively.

CONCLUSIONS:

Our results suggest bladder instillation with a DMSO cocktail may well be considered as first-line therapy for IC patients. However, there exists a subgroup of nonresponders who may have severe disease.

• Authors: Man-Jung Hung, Yi-Ting Chen, Pao-Sheng Shen, Shih-Tien Hsu, Gin-Den Chen, Esther Shih-Chu Ho
• Journal: International urogynecology journal (Int Urogynecol J) Vol. 23 Issue 11 Pg. 1533-9 (Nov 2012) ISSN: 1433-3023 [Electronic] England
• PMID: 22426874 (Publication Type: Journal Article)

Chemical References

• Free Radical Scavengers
• Dimethyl Sulfoxide

Topics

• Administration, Intravesical
• Adult
• Cystitis, Interstitial (drug therapy, physiopathology)
• Dimethyl Sulfoxide (administration & dosage, therapeutic use)
• Female
• Free Radical Scavengers (administration & dosage, therapeutic use)
• Hematuria (complications)
• Humans
• Kidney Diseases (complications)
• Middle Aged
• Regression Analysis
• Retrospective Studies
• Risk Factors
• Treatment Outcome
• Urinary Bladder Diseases (complications)
• Urodynamics (physiology)