Abstract | INTRODUCTION: METHODS: Nonrandomized prospective study of patients treated by multimodality therapy and operated on between January 2004 and June 2011. Second-line treatments were administered when appropriate. Survival and prognostic factors were analyzed by the Kaplan Meier method, log rank test, and Cox regression analysis. RESULTS: Twenty-five consecutive patients received neoadjuvant chemotherapy, 22 underwent EPP, and 17 received adjuvant radiotherapy. Over the same period, 54 consecutive patients underwent P/D and hyperthermic pleural lavage and received prophylactic radiotherapy and adjuvant chemotherapy. The 30-day mortality rate was 4.5%in the EPP group and nil in the P/D group. Fifteen patients (68%) in the EPP group and 15 (27.7%) in the P/D group experienced complications. There were no differences between the EPP and P/D groups for age, sex, histology, pathologic stage, and nodal status. Trimodality therapy was completed by 68%of the patients in the EPP group and 100%in the P/D group. Survival was significantly better in the P/D group: median survival was 23 months versus 12.8 months, 2-year survival was 49%versus 18.2 %, and 5-year survival was 30.1%versus 9%, respectively (p = 0.004). At multivariate analysis, epithelioid histology, P/D, and completeness of resection were independent prognostic factors. CONCLUSIONS:
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Authors | Loïc Lang-Lazdunski, Andrea Bille, Rohit Lal, Paul Cane, Emma McLean, David Landau, Jeremy Steele, James Spicer |
Journal | Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
(J Thorac Oncol)
Vol. 7
Issue 4
Pg. 737-43
(Apr 2012)
ISSN: 1556-1380 [Electronic] United States |
PMID | 22425923
(Publication Type: Journal Article)
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Topics |
- Aged
- Combined Modality Therapy
- Female
- Humans
- Male
- Mesothelioma
(mortality, pathology, therapy)
- Middle Aged
- Neoplasm Staging
- Pleural Neoplasms
(mortality, pathology, therapy)
- Pneumonectomy
(methods)
- Prospective Studies
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