Abstract |
Erlotinib is a selective epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor, which shows favorable antitumor activity against chemorefractory lung carcinoma, especially with EGFR gene mutations. We experienced a case in which oxy- genation and performance status improved in with low-dose erlotinib of 100mg/day administered every other day incidental- ly, although a dose of erlotinib 150mg/day daily is encouraged by the RECIST guideline. A 77-year-old male was diagnosed with bronchioloalveolar carcinoma(BAC)and given first-line combination chemotherapy of carboplatin and pemetrexed. However, antitumor activity was not satisfactory. His performance status(PS)was scored as 2 and home oxygen therapy (HOT)was introduced. As second-line chemotherapy, erlotinib was administered 100mg/day daily. However, the patient took the medication every other day at his own discretion, due to severe eruption and itching sensation. Since this case is classified as a nonmeasurable lesion according to the RECIST guideline, it was difficult to measure antitumor activity by tumor size. But improvement of oxygenation, with a performance status score of 0 and normalization of serum CEA level suggested that erlonitib administration of 100mg/day every other day showed antitumor activity.
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Authors | Kenzo Yuyama, Hisanori Matsushita, Kenichiro Egawa, Takeshi Osawa, Yusuke Tsubouchi, Takashi Takahashi, Hirotaro Miura |
Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 39
Issue 3
Pg. 433-5
(Mar 2012)
ISSN: 0385-0684 [Print] Japan |
PMID | 22421774
(Publication Type: Case Reports, English Abstract, Journal Article)
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Chemical References |
- Protein Kinase Inhibitors
- Quinazolines
- Erlotinib Hydrochloride
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Topics |
- Adenocarcinoma, Bronchiolo-Alveolar
(drug therapy)
- Aged
- Erlotinib Hydrochloride
- Humans
- Lung Neoplasms
(drug therapy)
- Male
- Protein Kinase Inhibitors
(administration & dosage, therapeutic use)
- Quinazolines
(administration & dosage, therapeutic use)
- Tomography, X-Ray Computed
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