Comparative study of tumor-specific transplantation antigens of MC-29 chicken hepatoma and Rous sarcoma virus-induced sarcomas in mice.

Abstract

Immunization of CBAT6T6 mice with MC-29 hepatoma antigen did not change the take of Rous sarcoma virus, Schmidt-Ruppin strain [RSV(SR)] mouse tumors after sc transplantation. Immunization with MC-29 hepatoma antigen only slightly increased the average survival time of the mice and significantly decreased tumor growth only at the minimal lethal dose level. Immunization of mice with MC-29 hepatoma antigen and immunization with chicken Rous sarcoma gave similar results; both elicited much less transplantation resistance than immunization with irradiated RSV(SR) mouse tumor cells. The data indicate that there are common tumor-specific transplantation antigens of MC-29 hepatoma and Rouse sarcoma, but further in vitro experiments are needed to prove this.

• Authors: G Elek, K Lapis, I Földes
• Journal: Journal of toxicology and environmental health (J Toxicol Environ Health) 1979 Mar-May Vol. 5 Issue 2-3 Pg. 529-36 ISSN: 0098-4108 [Print] United States
• PMID: 224208 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antigens, Neoplasm
• Antigens, Viral
• Histocompatibility Antigens

Topics

• Animals
• Antigens, Neoplasm (administration & dosage)
• Antigens, Viral
• Avian Leukosis Virus (immunology)
• Chickens
• Female
• Histocompatibility Antigens (administration & dosage)
• Liver Neoplasms, Experimental (immunology)
• Male
• Mice
• Mice, Inbred CBA
• Sarcoma, Avian (immunology)
• Tumor Virus Infections (immunology)