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[Methods for the prevention and treatment of toxico-hypoxic encephalopathy in patients with acute severe poisoning].

Abstract
The study included 147 patients with toxico-hypoxic encephalopathy resulting from acute poisoning. It was shown that intensive therapy with cytoflavin (20 ml in 400 ml of 5% glucose solution twice daily for 7 days) reduced severity of hypoxic brain lesions and suppression of CNS as apparent from the improvement of its bioelectric activity. The recovery of CNS regulatory action on the life-sustaining systems of the body promoted normalization of the respiratory component of oxygen transport. The improvement of the patients' conditions in the acute phase contributed to accelerated recovery of cognitive-amnestic functions and social adaptation. Cytoflavin therapy improved the clinical picture of toxico-hypoxic encephalopathy due to the reduction in the duration of the comatose state from 45.3 +/- 8.2 to 27.7 +/- 6.9 hr and the decrease in the frequency of secondary pulmonary complications from 72.7 to 35.9%.
Authors
JournalKlinicheskaia meditsina (Klin Med (Mosk)) Vol. 89 Issue 6 Pg. 56-9 ( 2011) ISSN: 0023-2149 [Print] Russia (Federation)
PMID22420197 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Antidotes
  • Drug Combinations
  • Neuroprotective Agents
  • Succinates
  • cytoflavin
  • Vitamin B Complex
  • Niacinamide
  • Flavin Mononucleotide
  • Inosine Diphosphate
Topics
  • Acute Disease
  • Adult
  • Antidotes (administration & dosage, therapeutic use)
  • Drug Combinations
  • Electroencephalography
  • Flavin Mononucleotide (administration & dosage)
  • Humans
  • Hypoxia, Brain (chemically induced, drug therapy, prevention & control)
  • Inosine Diphosphate (administration & dosage)
  • Neuroprotective Agents (administration & dosage)
  • Niacinamide (administration & dosage)
  • Poisoning (drug therapy)
  • Severity of Illness Index
  • Succinates (administration & dosage)
  • Vitamin B Complex (administration & dosage)

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