Abstract |
The study included 147 patients with toxico- hypoxic encephalopathy resulting from acute poisoning. It was shown that intensive therapy with cytoflavin (20 ml in 400 ml of 5% glucose solution twice daily for 7 days) reduced severity of hypoxic brain lesions and suppression of CNS as apparent from the improvement of its bioelectric activity. The recovery of CNS regulatory action on the life-sustaining systems of the body promoted normalization of the respiratory component of oxygen transport. The improvement of the patients' conditions in the acute phase contributed to accelerated recovery of cognitive-amnestic functions and social adaptation. Cytoflavin therapy improved the clinical picture of toxico- hypoxic encephalopathy due to the reduction in the duration of the comatose state from 45.3 +/- 8.2 to 27.7 +/- 6.9 hr and the decrease in the frequency of secondary pulmonary complications from 72.7 to 35.9%.
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Authors | |
Journal | Klinicheskaia meditsina
(Klin Med (Mosk))
Vol. 89
Issue 6
Pg. 56-9
( 2011)
ISSN: 0023-2149 [Print] Russia (Federation) |
PMID | 22420197
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Antidotes
- Drug Combinations
- Neuroprotective Agents
- Succinates
- cytoflavin
- Vitamin B Complex
- Niacinamide
- Flavin Mononucleotide
- Inosine Diphosphate
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Topics |
- Acute Disease
- Adult
- Antidotes
(administration & dosage, therapeutic use)
- Drug Combinations
- Electroencephalography
- Flavin Mononucleotide
(administration & dosage)
- Humans
- Hypoxia, Brain
(chemically induced, drug therapy, prevention & control)
- Inosine Diphosphate
(administration & dosage)
- Neuroprotective Agents
(administration & dosage)
- Niacinamide
(administration & dosage)
- Poisoning
(drug therapy)
- Severity of Illness Index
- Succinates
(administration & dosage)
- Vitamin B Complex
(administration & dosage)
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