In recent years,
polyphenols have attracted considerable attention as agents that protect cells or molecules from oxidative myocardial injury. The aim of the study was to prove the cardioprotective benefits of the
flavonoid morin in
isoproterenol-induced myocardial infarcted rats. Male Wistar rats are treated orally with
morin (10 and 20 mg/kg) daily for a period of 21 days. After 21 days of pretreatment,
isoproterenol (100 mg/kg) was injected subcutaneously to rats at an interval of 24 h for 2 days to induce
myocardial infarction. Electrocardiographical abnormalities and
biomarkers were measured in normal and experimental rats.
Isoproterenol-induced myocardial infarcted rats showed significant (p<0.05) increase in the levels of cardiac markers. Pretreatment with
morin regulated the abnormalities in electrocardiograph and
biomarkers. The lipid peroxidation products were increased and indicated the increased lipid peroxidation in
isoproterenol-induced myocardial infarcted rats. The rats pretreated with
morin significantly reduced lipid peroxidation. The altered lipid metabolism was observed in
isoproterenol-induced myocardial infarcted rats and in pretreatment with
morin-regulated lipid metabolism. Histopathological study evidenced that the pretreatment with
morin inhibited myocardial damage. The results of this study proved the protective effect of
morin as pretreatment and are rational to understand the beneficial effects of
morin on cardioprotection against myocardial injury. Based on the results, the cardioprotective ability of
morin on human beings can be studied in the future.