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Efficacy of maduramicin ammonium against coccidiosis in turkeys under laboratory and floor-pen conditions.

Abstract
Experimental infections with field isolates of Eimeria meleagrimitis, E. adenoeides, E. gallopavonis, and E. dispersa in turkey poults were used to test the efficacy of maduramicin ammonium at 2.5-10 ppm in laboratory experiments. Infection with single or mixed species of coccidia reduced the weight gain of unmedicated infected controls and caused 18.1-65% mortality in two experiments. Maduramicin ammonium given at 5-7 ppm prevented mortality, significantly reduced droppings scores and oocyst passage, and improved weight gain to near that of the unmedicated uninfected controls. Maduramicin ammonium was tested at 4-7 ppm in a floor-pen trial lasting 10 weeks. Mortality from coccidiosis averaged 11.9% in unmedicated controls, compared with 0.6% with 4 ppm of maduramicin or no mortality with 5-7 ppm. Average weight gain and feed conversion at 10 weeks were significantly improved over unmedicated infected controls when maduramicin ammonium was given at 5-7 ppm. These results suggest that maduramicin ammonium is highly efficacious against field isolates of Eimeria in turkeys, especially within the range of 5-7 ppm in the feed.
AuthorsL R McDougald, A L Fuller, G F Mathis, G T Wang
JournalAvian diseases (Avian Dis) 1990 Jul-Sep Vol. 34 Issue 3 Pg. 634-8 ISSN: 0005-2086 [Print] United States
PMID2241692 (Publication Type: Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Coccidiostats
  • Lactones
  • maduramicin
Topics
  • Animals
  • Anti-Bacterial Agents (therapeutic use)
  • Coccidiosis (drug therapy, veterinary)
  • Coccidiostats (therapeutic use)
  • Female
  • Lactones (therapeutic use)
  • Male
  • Poultry Diseases (drug therapy)
  • Random Allocation
  • Turkeys (parasitology)

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