The FCGR2B rs10917661 polymorphism may confer susceptibility to ankylosing spondylitis in Han Chinese: a case-control study.

Abstract

OBJECTIVE:

Single-nucleotide polymorphisms (SNPs) in the Fc gamma receptor IIB (FCGR2B) gene have recently been found to be associated with several human autoimmune diseases. We undertook the current study to investigate the influence of these polymorphisms on the risk of ankylosing spondylitis (AS).

METHOD:

A total of 306 patients with AS from Anhui, China, fulfilling the modified New York Criteria, and 300 matched healthy controls were analysed. All subjects were genotyped for two SNPs (rs1050501, rs10917661) in the FCGR2B gene, and the SNaPshot Assay was used for genotyping.

RESULTS:

SNP rs10917661 was significantly associated with AS [C vs. T: odds ratio (OR) 1.723, 95% confidence interval (CI) 1.086-2.733, p = 0.020; genotype: p = 0.026] whereas no association was found for rs1050501. Furthermore, no haplotype was found to be associated with AS.

CONCLUSION:

These findings indicated that rs10917661 may be a novel SNP involved in AS genetic predisposition in the Han Chinese population.

• Authors: Z-H Duan, F-M Pan, Z Zeng, T-C Zhang, S Wang, G-X Li, Y Mei, J Gao, R Ge, D-Q Ye, Y-F Zou, S-Q Xu, J-H Xu, L Zhang
• Journal: Scandinavian journal of rheumatology (Scand J Rheumatol) Vol. 41 Issue 3 Pg. 219-22 (May 2012) ISSN: 1502-7732 [Electronic] England
• PMID: 22416796 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• FCGR2B protein, human
• Receptors, IgG

Topics

• Adult
• Asian People (genetics)
• Case-Control Studies
• China (ethnology)
• Female
• Gene Frequency
• Genetic Predisposition to Disease (genetics)
• Haplotypes (genetics)
• Humans
• Male
• Polymorphism, Single Nucleotide (genetics)
• Receptors, IgG (genetics)
• Spondylitis, Ankylosing (ethnology, genetics)
• Young Adult