[Synergism of antitumor activity of gemcitabine and dioxadet in mice with ascitic Ehrlich's tumor].

Abstract

Antitumor activity of a new cytostatic drug combination of gemcitabine and dioxadet have been studied in 86 female SHR mice transplanted with 5 x 10(6) of ascitic Ehrlich's tumor cells each. All mice received a single injection of gemcitabine, dioxadet on combination 48 hams after tumor cells introduction. In first series, experimental animals received maximal tolerable dose of gemcitabine (25 mg/kg) and one half of dioxadet maximal tolerable dose (2.5 mg/kg). In the second series of experiments, the animals received 5 mg/kg of dioxadet along with the same gemcitabine dose. Effect of drugs was compared using the time to ascites detection, body weight increase, and survival time. Gemcitabine and dioxadet administered separately and in combination inhibited the growth of ascitic Ehrlich's tumor in the mice. In both series of experiments antineoplastic activity of gemcitabine and dioxadet combination was significantly higher in comparison to the control groups receiving these drugs separately. The highest antineoplastic activity of the gemcitabine and dioxadet combination was observed when the maximal tolerable doses of both drugs was applied. However, the tumor cells growth was also significantly inhibited in mice receiving half of dioxadet dose. Synergism of antitumor activity of gemcitabine and dioxadet was not accompanied by appreciable increase in toxicity.

• Authors: D Kh Latipova, M L Gershanovich, A N Stukov, T Iu Semiglazova, L V Filatova, A A Tarasenkova, S F Vershinina, S A Kon'kov, I M Krylova, V G Bespalov, A V Panchenko, Ia G Murazov
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 57 Issue 6 Pg. 767-70 ( 2011) ISSN: 0507-3758 [Print] Russia (Federation)
• PMID: 22416395 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Triazines
• Deoxycytidine
• dioxadet
• Gemcitabine

Topics

• Animals
• Antimetabolites, Antineoplastic (pharmacology)
• Antineoplastic Combined Chemotherapy Protocols (pharmacology)
• Carcinoma, Ehrlich Tumor (drug therapy)
• Deoxycytidine (administration & dosage, analogs & derivatives, pharmacology)
• Drug Administration Schedule
• Drug Synergism
• Female
• Maximum Tolerated Dose
• Mice
• Mice, Inbred Strains
• Time Factors
• Triazines (administration & dosage, pharmacology)
• Weight Gain
• Gemcitabine