Abstract | BACKGROUND: Colorectal carcinogenesis is one of the most common cancers/lethal diseases. Chronic inflammation is considered a risk factor for colorectal cancer. Hesperetin, a flavonone found in citrus fruits and oranges is shown to possess potent growth inhibitory effects against various human cancer cells. It possesses anti-inflammatory and antioxidant properties. AIM OF THE SCOPE: In the present study, we have evaluated the chemopreventive efficacy of hesperetin against rat colon carcinogenesis in male Wistar rats. METHODS: Group 1 served as control, received modified pellet diet and group 2 rats received 20 mg/kg body weight of hesperetin p.o. every day. Groups 3-6 rats were given subcutaneous injections of 1,2-dimethylhydrazine ( DMH, 20 mg/kg body weight) once a week for 15 consecutive weeks. In addition, rats in group 4 received hesperetin as in group 2 for the first 15 weeks (initiation), group 5 rats received hesperetin as in group 2 after the last injection of DMH and continued till the end of the experimental period (postinitiation). Group 6 rats received hesperetin as in group 2 throughout the entire experimental period of 32 weeks. RESULTS: CONCLUSIONS:
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Authors | N Nalini, S Aranganathan, J Kabalimurthy |
Journal | Toxicology mechanisms and methods
(Toxicol Mech Methods)
Vol. 22
Issue 5
Pg. 397-408
(Jun 2012)
ISSN: 1537-6524 [Electronic] England |
PMID | 22409373
(Publication Type: Journal Article)
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Chemical References |
- Anticarcinogenic Agents
- Vascular Endothelial Growth Factor A
- vascular endothelial growth factor A, rat
- Epidermal Growth Factor
- Hesperidin
- Cyclooxygenase 2
- Ptgs2 protein, rat
- 1,2-Dimethylhydrazine
- hesperetin
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Topics |
- 1,2-Dimethylhydrazine
(toxicity)
- Animals
- Anticarcinogenic Agents
(administration & dosage, therapeutic use)
- Apoptosis
(drug effects)
- Blotting, Western
- Cell Proliferation
(drug effects)
- Colonic Neoplasms
(chemically induced, metabolism, pathology, prevention & control)
- Cyclooxygenase 2
(biosynthesis, genetics)
- Enzyme-Linked Immunosorbent Assay
- Epidermal Growth Factor
(metabolism)
- Hesperidin
(administration & dosage, therapeutic use)
- Male
- Rats
- Rats, Wistar
- Real-Time Polymerase Chain Reaction
- Vascular Endothelial Growth Factor A
(metabolism)
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