Histological evaluation of rat larynx in experimental polycystic ovary syndrome model.

This study aimed at studying the histopathological effects of hyperandrogenemia and estrogen deficiency on larynx mucosa in experimentally designed polycystic ovary syndrome of female rats. Two groups of experimental polycystic ovary syndrome model were composed in healthy female rats by per oral letrozole administration of for 21 and 42 days. Also a control group which only took vehicle (saline) for 42 days was designed. Laryngeal mucosa and ovaries of all animals were examined histopathologically by light microscopy and the serum hormone levels were analyzed using a solid-phase, two-site chemiluminescent enzyme immunometric assay. Statistically significant edema, vascular engorgement, inflammation, cilia loss and differentiation of goblet cell distribution were observed when the control group and study groups were compared (p < 0.01). In serum hormonal analysis there was a significant increase in levels of androgens and decrease in levels of estrogens. In addition, polycystic appearance of ovaries in letrozole-administered groups and normal appearance of ovaries in control group have been proven histopathologically. Polycystic ovary syndrome which causes estrogen deficiency and hyperandrogenemia in fertile ages resulted in histopathological changes in laryngeal mucosa.
AuthorsHande Senem Deveci, Ildem Deveci, Mehmet Habesoglu, Mehmet Sürmeli, Vefa Kınıs, Murat Eriman, Pembegul Gunes, Murat Yekrek, Erol Egeli
JournalEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (Eur Arch Otorhinolaryngol) Vol. 269 Issue 8 Pg. 1945-50 (Aug 2012) ISSN: 1434-4726 [Electronic] Germany
PMID22407189 (Publication Type: Journal Article)
Chemical References
  • Testosterone
  • Estradiol
  • Animals
  • Case-Control Studies
  • Cilia (pathology)
  • Disease Models, Animal
  • Estradiol (blood)
  • Female
  • Goblet Cells (pathology)
  • Hyperandrogenism (etiology, pathology)
  • Laryngeal Mucosa (pathology)
  • Ovary (pathology)
  • Polycystic Ovary Syndrome (complications, pathology)
  • Rats
  • Rats, Wistar
  • Testosterone (blood)

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