Platycodi Radix suppresses development of atopic dermatitis-like skin lesions.

Abstract	Platycodi Radix has been used to treat chronic diseases, such as bronchitis, asthma, and hyperlipidemia. In this study, we examined the effect of an aqueous extract, Changkil (CK), from the root of Platycodi Radix on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD)-like skin lesions. Administration of CK onto DNCB-induced AD-like skin lesions in NC/Nga mice ameliorated lesion intensity scores, levels of IgE, thymus and activation-regulated chemokine (TARC), TNF-α, and IL-4 in serum and ears. In contrast, CK increased level of the immunosuppressive cytokine IL-10. Histopathological examination showed reduced thickness of the epidermis/dermis and dermal infiltration of inflammatory cells in the ears. CK also suppressed TNF-α/IFN-γ-induced mRNA expression and production of TARC in HaCaT cells. CK exerts beneficial effects on AD symptoms, suggesting that CK is an effective potential therapeutic agent for AD.
Authors	Jae Ho Choi, Eun Hee Han, Bong Hwan Park, Hyung Gyun Kim, Yong Pil Hwang, Young Chul Chung, Young Chun Lee, Hye Gwang Jeong
Journal	Environmental toxicology and pharmacology (Environ Toxicol Pharmacol) Vol. 33 Issue 3 Pg. 446-52 (May 2012) ISSN: 1872-7077 [Electronic] Netherlands
PMID	22407167 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright	Copyright Â© 2012 Elsevier B.V. All rights reserved.
Chemical References	Anti-Allergic Agents Ccl17 protein, mouse Changkil Chemokine CCL17 Cytokines Dinitrochlorobenzene Irritants Plant Extracts RNA, Messenger Immunoglobulin E
Topics	Animals Anti-Allergic Agents (therapeutic use) Cell Line Cell Survival Chemokine CCL17 (blood) Cytokines (blood, genetics) Dermatitis, Atopic (drug therapy, metabolism) Dinitrochlorobenzene Disease Models, Animal Humans Immunoglobulin E (blood) Irritants Male Mice Plant Extracts (therapeutic use) Plant Roots Platycodon RNA, Messenger (metabolism)

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