HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Diagnostics of primary aldosteronism: is obligatory use of confirmatory tests justified?

AbstractINTRODUCTION:
Assessment of the renin-angiotensin-aldosterone system has been recently granted a much greater role in the evaluation of patients with arterial hypertension. There is no single test efficient in selection of patients for second-step etiological investigation.
METHODS:
Altogether, 198 consecutive patients--119 women (60%) and 79 men (40%)--hospitalized in years 2009-2011 at the Clinical Department of Endocrinology Medical University of Bialystok were diagnosed with primary aldosteronism. In each patient, plasma renin activity and plasma aldosterone concentration (basic and after 2 l NaCl infusion) were evaluated.
RESULTS:
The percentage of patients with plasma aldosterone concentration ≥ 15 ng/ml was 53 and the percentage of patients with plasma renin activity ≤ 0.1 ng/ml/h was 20. The percentage of patients screened for primary aldosteronism in which the aldosterone:renin ratio exceeded consecutive cut-offs of 20, 30, 40 and 50 were respectively 57, 45, 34 and 29. Among 15 patients in which plasma aldosterone concentration after infusion of 2 l of saline was ≥ 6.5 ng/dl (8.6%), 13 (6.6%) were diagnosed with primary aldosteronism.
CONCLUSION:
The obligatory use of tests confirming autonomy of aldosterone secretion in patients screened for primary aldosteronism seems cost-effective in limiting the number of patients for further diagnosis.
AuthorsJanusz Myśliwiec, Łukasz Zukowski, Anna Grodzka, Agata Piłaszewicz, Szymon Dragowski, Maria Górska
JournalJournal of the renin-angiotensin-aldosterone system : JRAAS (J Renin Angiotensin Aldosterone Syst) Vol. 13 Issue 3 Pg. 367-71 (Sep 2012) ISSN: 1752-8976 [Electronic] England
PMID22406967 (Publication Type: Journal Article)
Chemical References
  • Sodium Chloride
  • Aldosterone
  • Renin
Topics
  • Aldosterone (blood)
  • Diagnostic Tests, Routine (methods)
  • Female
  • Humans
  • Hyperaldosteronism (blood, diagnosis)
  • Male
  • Middle Aged
  • ROC Curve
  • Renin (blood)
  • Reproducibility of Results
  • Sodium Chloride (administration & dosage)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: