Efficacy of artemether-lumefantrine in area of high malaria endemicity in India and its correlation with blood concentration of lumefantrine.

Abstract	This study was conducted to correlate blood concentrations of lumefantrine with treatment outcome for patients with Plasmodium falciparum malaria when the drug was given without specific instructions for administration with food. Patients with P. falciparum malaria in the highly endemic state of Orissa, India, were enrolled during 2008 and followed-up for 28 days after admistration of artemether-lumefantrine for three days according to a World Health Organization protocol. Drug concentration in whole blood was determined by using blood spots placed on filter paper on day 7. The technology is suitable for field studies. One hundred percent of the patients had an adequate clinical and parasitological response. These results confirm the efficacy of artemether-lumefantrine in persons from poor tribal communities when given without specific instructions regarding co-administration with food, despite high inter-individual variability in blood concentrations of lumefantrine.
Authors	Neena Valecha, Suman Mohanty, Prakriti Srivastava, Surya Sharma, Prajesh Tyagi, Yngve Bergqvist, Pascal Ringwald
Journal	The American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 86 Issue 3 Pg. 395-7 (Mar 2012) ISSN: 1476-1645 [Electronic] United States
PMID	22403306 (Publication Type: Clinical Trial, Journal Article)
Chemical References	Antimalarials Artemether, Lumefantrine Drug Combination Artemisinins Drug Combinations Ethanolamines Fluorenes Lumefantrine
Topics	Adolescent Adult Aged Antimalarials (blood, therapeutic use) Artemether, Lumefantrine Drug Combination Artemisinins (administration & dosage) Child Child, Preschool Drug Combinations Drug Therapy, Combination Ethanolamines (administration & dosage, blood, therapeutic use) Female Fluorenes (administration & dosage, blood, therapeutic use) Follow-Up Studies Humans India (epidemiology) Infant Lumefantrine Malaria, Falciparum (drug therapy, epidemiology) Male Middle Aged Patient Compliance Plasmodium falciparum (pathogenicity) Treatment Outcome Young Adult

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!