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A patient with tyrosine kinase 2 deficiency without hyper-IgE syndrome.

Abstract
We describe a Turkish patient with tyrosine kinase 2 deficiency who suffered from disseminated Bacille Calmette-Guerin infection, neurobrucellosis, and cutaneous herpes zoster infection. Tyrosine kinase 2 deficiency should be considered in patients susceptible to herpes viruses and intramacrophage pathogens even in the absence of atopy, high serum IgE, and staphylococcal disease.
AuthorsSara S Kilic, Mustafa Hacimustafaoglu, Stéphanie Boisson-Dupuis, Alexandra Y Kreins, Audrey V Grant, Laurent Abel, Jean-Laurent Casanova
JournalThe Journal of pediatrics (J Pediatr) Vol. 160 Issue 6 Pg. 1055-7 (Jun 2012) ISSN: 1097-6833 [Electronic] United States
PMID22402565 (Publication Type: Case Reports, Journal Article, Research Support, N.I.H., Extramural)
CopyrightCopyright © 2012 Mosby, Inc. All rights reserved.
Chemical References
  • TYK2 Kinase
Topics
  • Child
  • Diagnosis, Differential
  • Follow-Up Studies
  • Humans
  • Immunologic Deficiency Syndromes (diagnosis, enzymology)
  • Job Syndrome (diagnosis)
  • Magnetic Resonance Imaging
  • Male
  • TYK2 Kinase (blood, deficiency)

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