Abstract | OBJECTIVE: METHOD: Women diagnosed with mild-to-moderate severity postpartum depression according to DSM-IV-TR criteria were enrolled in an 8-week, randomized, double-blind, placebo-controlled study. Participants received 12 sessions of focused brief dynamic psychotherapy (BDP) concurrently with 8-week sertraline or placebo treatment, followed by a 4-week open phase. Primary outcomes were depression scores measured by the Montgomery-Asberg Depression Rating Scale (MADRS) and remission rates. The study was conducted in a referral center from May 2008 to September 2010. RESULTS: Forty of 42 women randomized into the study entered the intent-to-treat analysis. A significant time effect for the MADRS was observed (F4,35 = 21.3, P < .0001); however, no time-by-group effect was found for any outcome measure. Response rates were 70% and 55% for the drug and placebo groups, respectively, and remission rates were 65% and 50%, respectively, with no significant difference between groups. CONCLUSION: While both treatment groups improved significantly, the results of the present study did not demonstrate a significant benefit for sertraline over placebo as an add-on treatment to focused BDP in mild-to-moderate postpartum depression. Because of the study's small sample, the results cannot be viewed as definitive, and a much larger study is needed to confirm these results. Furthermore, the promising potential of focused BDP as an intervention in this population should be studied under controlled conditions. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01028482.
|
Authors | Miki Bloch, Hadas Meiboom, Merona Lorberblatt, Irit Bluvstein, Inbar Aharonov, Shaul Schreiber |
Journal | The Journal of clinical psychiatry
(J Clin Psychiatry)
Vol. 73
Issue 2
Pg. 235-41
(Feb 2012)
ISSN: 1555-2101 [Electronic] United States |
PMID | 22401479
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Copyright | © Copyright 2012 Physicians Postgraduate Press, Inc. |
Chemical References |
- Antidepressive Agents
- Placebos
- Sertraline
|
Topics |
- Adolescent
- Adult
- Antidepressive Agents
(therapeutic use)
- Combined Modality Therapy
(methods, psychology, statistics & numerical data)
- Depression, Postpartum
(drug therapy, therapy)
- Double-Blind Method
- Female
- Humans
- Middle Aged
- Placebos
- Psychiatric Status Rating Scales
(statistics & numerical data)
- Psychotherapy, Brief
(methods, statistics & numerical data)
- Remission Induction
(methods)
- Sertraline
(therapeutic use)
|