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Methanol extract of Bauhinia purpurea leaf possesses anti-ulcer activity.

AbstractOBJECTIVE:
The aim of the present study was to determine the anti-ulcer activity of a methanol extract of Bauhinia purpurea leaf (MEBP).
MATERIALS AND METHODS:
MEBP was administered at doses of 100, 500 and 1,000 mg/kg and its effects on acute toxicity, absolute ethanol- and indomethacin-induced gastric ulceration, and pyloric ligation tests in rats were investigated.
RESULTS:
At a dose of 5,000 mg/kg, MEBP did not cause any signs of toxicity in rats when given orally. Oral administration of MEBP exerted anti-ulcer activity (p < 0.05) in all models tested. However, a dose-dependent protection was observed only in the indomethacin-induced gastric ulceration model. Histological studies supported the observed anti-ulcer activity of MEBP. In the pyloric ligation assay, MEBP significantly increased gastric wall mucus secretion (p < 0.05), but did not affect the acidity of the gastric contents.
CONCLUSION:
MEBP exhibited anti-ulcer activity, which could be due to the presence of flavonoids, saponins or other polyphenols, thereby validating the traditional use of B. purpurea in the treatment of ulcers.
AuthorsZ A Zakaria, E E Abdul Hisam, M Norhafizah, M S Rofiee, F Othman, A H Hasiah, M Vasudevan
JournalMedical principles and practice : international journal of the Kuwait University, Health Science Centre (Med Princ Pract) Vol. 21 Issue 5 Pg. 476-82 ( 2012) ISSN: 1423-0151 [Electronic] Switzerland
PMID22398984 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 S. Karger AG, Basel.
Chemical References
  • Gastrointestinal Agents
  • Plant Extracts
  • Omeprazole
  • Indomethacin
  • Methanol
Topics
  • Animals
  • Bauhinia
  • Dose-Response Relationship, Drug
  • Gastrointestinal Agents (administration & dosage, pharmacology, therapeutic use)
  • Indomethacin (pharmacology)
  • Male
  • Methanol (chemistry)
  • Omeprazole (pharmacology)
  • Plant Extracts (administration & dosage, chemistry, pharmacology, therapeutic use)
  • Plant Leaves
  • Rats
  • Rats, Sprague-Dawley
  • Stomach Ulcer (chemically induced)
  • Ulcer (drug therapy)

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