Abstract | OBJECTIVE: The aim of the present study was to determine the anti- ulcer activity of a methanol extract of Bauhinia purpurea leaf ( MEBP). MATERIALS AND METHODS:
MEBP was administered at doses of 100, 500 and 1,000 mg/kg and its effects on acute toxicity, absolute ethanol- and indomethacin-induced gastric ulceration, and pyloric ligation tests in rats were investigated. RESULTS: At a dose of 5,000 mg/kg, MEBP did not cause any signs of toxicity in rats when given orally. Oral administration of MEBP exerted anti- ulcer activity (p < 0.05) in all models tested. However, a dose-dependent protection was observed only in the indomethacin-induced gastric ulceration model. Histological studies supported the observed anti- ulcer activity of MEBP. In the pyloric ligation assay, MEBP significantly increased gastric wall mucus secretion (p < 0.05), but did not affect the acidity of the gastric contents. CONCLUSION:
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Authors | Z A Zakaria, E E Abdul Hisam, M Norhafizah, M S Rofiee, F Othman, A H Hasiah, M Vasudevan |
Journal | Medical principles and practice : international journal of the Kuwait University, Health Science Centre
(Med Princ Pract)
Vol. 21
Issue 5
Pg. 476-82
( 2012)
ISSN: 1423-0151 [Electronic] Switzerland |
PMID | 22398984
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 S. Karger AG, Basel. |
Chemical References |
- Gastrointestinal Agents
- Plant Extracts
- Omeprazole
- Indomethacin
- Methanol
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Topics |
- Animals
- Bauhinia
- Dose-Response Relationship, Drug
- Gastrointestinal Agents
(administration & dosage, pharmacology, therapeutic use)
- Indomethacin
(pharmacology)
- Male
- Methanol
(chemistry)
- Omeprazole
(pharmacology)
- Plant Extracts
(administration & dosage, chemistry, pharmacology, therapeutic use)
- Plant Leaves
- Rats
- Rats, Sprague-Dawley
- Stomach Ulcer
(chemically induced)
- Ulcer
(drug therapy)
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