Abstract | BACKGROUND AND AIM: METHODS: The following databases were searched: MEDLINE, Pubmed, Scopus, Web of Knowledge, Cinicaltrials.gov and the Cochrane Central Register of Controlled Trials using the terms ' inflammatory bowel disease' ' Crohn's disease' ' ulcerative colitis' ' colitis' [and] ' vitamin D'. Both human and animal studies published in English language were examined. The reference lists of included studies and review articles were manually searched for any relevant studies. RESULTS: Four studies were included in this systematic review. All reported an improvement in disease activity with vitamin D supplementation. The only high quality human study reported a non-significant reduction of relapse rate for Crohn's disease. No major adverse effects of vitamin D supplementation were reported. CONCLUSIONS: Although there is some evidence that supplemental vitamin D, as an adjunctive treatment, may help in controlling colitis, this evidence is not enough to justify using vitamin D in treating inflammatory bowel disease (IBD). Large high quality placebo-controlled randomised controlled trials are needed to explore a possible benefit of using vitamin D in treating IBD.
|
Authors | Imogen Nicholson, A Mark Dalzell, Wael El-Matary |
Journal | Journal of Crohn's & colitis
(J Crohns Colitis)
Vol. 6
Issue 4
Pg. 405-11
(May 2012)
ISSN: 1876-4479 [Electronic] England |
PMID | 22398085
(Publication Type: Journal Article, Review, Systematic Review)
|
Copyright | Crown Copyright © 2012. Published by Elsevier B.V. All rights reserved. |
Chemical References |
|
Topics |
- Animals
- Colitis
(drug therapy)
- Humans
- Inflammatory Bowel Diseases
(drug therapy)
- Vitamin D
(therapeutic use)
- Vitamins
(therapeutic use)
|