Abstract | BACKGROUND AND AIM: MATERIALS AND METHODS: The study group consisted of 18 pouch patients with underlying ulcerative colitis (UC) and PSC who were treated with 9 mg daily of budesonide for their underlying pre- pouch ileitis and pouchitis for 1-3 months followed by 3-6 mg maintenance for another 9 months. Demographic and clinical variables were analyzed. RESULTS: The mean age was 39.4±12.4 years (range, 21-59 years). There was no significant change in aspartate aminotransferase (AST) [median (interquartile range) (IQR) 32 (25, 43.8) vs. 35.5 (25.5, 53), p=0.35], alanine aminotransferase (ALT) [37.5 (25.5, 49.5) vs. 40 (30, 84.3), p=0.29], alkaline phosphatase [142.5 (98.5, 264.5) vs. 126 (94.3, 189.5), p=0.35], serum bilirubin [0.7 (0.4, 1.3) vs., 0.6 (0.4, 1.6), p=0.13] or albumin levels [4.3 (3.9, 4.4) vs. 4.2 (3.8, 4.4), p=0.22] at the end of the treatment period (1 year). The revised Mayo Risk Score did not change significantly and three patients required evaluation for liver transplantation during treatment. There was a significant improvement in the endoscopy subscores in the afferent limb and pouch after a year of budesonide treatment (p=0.001). CONCLUSIONS: Oral budesonide appears to have no impact on liver function tests in pouch patients with PSC. However it significantly improved afferent limb and pouch inflammation in IPAA patients.
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Authors | Udayakumar Navaneethan, Preethi G K Venkatesh, Ana E Bennett, Viral Patel, Jeffrey Hammel, Ravi P Kiran, Arthur J McCullough, Bo Shen |
Journal | Journal of Crohn's & colitis
(J Crohns Colitis)
Vol. 6
Issue 5
Pg. 536-42
(Jun 2012)
ISSN: 1876-4479 [Electronic] England |
PMID | 22398056
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Biomarkers
- Glucocorticoids
- Budesonide
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Topics |
- Adult
- Anal Canal
(surgery)
- Anastomosis, Surgical
- Biomarkers
(blood)
- Budesonide
(administration & dosage, therapeutic use)
- Cholangitis, Sclerosing
(blood, complications, drug therapy)
- Colitis, Ulcerative
(blood, complications, surgery)
- Colonic Pouches
- Dose-Response Relationship, Drug
- Female
- Follow-Up Studies
- Glucocorticoids
(administration & dosage, therapeutic use)
- Humans
- Liver Function Tests
- Male
- Middle Aged
- Pouchitis
(blood, complications, drug therapy)
- Proctocolectomy, Restorative
- Prospective Studies
- Time Factors
- Treatment Outcome
- Young Adult
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